SUBSTANCES & METHODS

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PROHIBITED AT ALL TIMES (IN-AND OUT-OF-COMPETITION)
All prohibited substances in this class are Specified Substances.

Any pharmacological substance which is not addressed by any of the subsequent sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g. drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited at all times

S1 – ANABOLIC AGENTS

Anabolic agents (ANABOLIC AGENTS) are substances that occur naturally or are artificially produced with properties similar to male hormones such as NANDROLONE, METANDIENONE,TESTOSTERONE, etc. They affect muscle g owth by causing protein synthesis and salt and water retention in muscle tissue, making muscles grow larger and heavier. However, studies have shown that sooner or later, muscles that grow from stimulation will retain water and salt even though they don’t increase in size due to protein synthesis. Additionally, this also causes muscle growth to be temporary and can be used for a short time during training and competition. This group is commonly used in sports that require high muscle mass in large amounts and is used continuously for a long time.

Pharmacological Effects

Dizziness
Drowsiness
Growth spurt
Cancer risk
High blood pressure

Side Effects in Males

Testicular atrophy
Reduced sexual function
Reduced sperm production

Side Effects in Females

Voice cracking, deep voice, Mood swings headache, depression
Irregular menstruation

S2 – PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCESAND MIMETICS

Peptide Hormones, Growth Factors and Related Substances that affect hormone for growth, substances with similar properties, and other substances with similar chemical structures or biological effects.

Example: ERYTHROPOIETINS (EPO) (Erythro protein)
Helps the body produce oxygen better. However an lead to death because EPO may cause blood thickening and avoid medical attempts to stop blood clotting, and blood clots in blood vessels may occur.

Side Effects

High blood pressure
Heart works too hard until heart disease develops
Heart stops or sudden cardiac arrest
Makes body weak

Example: GROWTH HORMONE (Growth hormone)
Makes muscles and bones strong and can restore flexibility faster.

Side Effects

Disproportionate growth such as large face, chin, forehead, and jaw which cannot be reversed
Heart disease which leads to high blood
pressure and heart failure
Liver, diabetes, and blurred vision
Liver inflammation

And other substances related to factors affecting growth or growth inhibitors that affect muscle fiber formation in the muscle fiber area connected to blood vessels and using energy to restore muscle fiber shape.

S3 – BETA-2 AGONISTS

Used in medical treatment for various conditions such as heart disease and other circulatory system diseases. Therefore, athletes who need to use these substances should check through WWW.GLOBALDRO.COM before use or consult with the Doping Control Agency (DCAT).

Side Effects

Heart rate irregularity
Nausea
Drowsiness
Headache
Dizziness
Heart failure
Insomnia

S4 – HORMONE AND METABOLIC MODULATORS

Hormone and Metabolism Control Substances
For example: Hormone inhibitors (ESTROGEN) and (PROGESTERONE) – female hormones that play a role in sexual development, female
characteristics, menstruation, pregnancy, and are often used to treat breast cancer or irregular menstruation, or as birth control.

Hormonal abnormalities
Physical characteristics change to opposite gender characteristics (e.g., depression, deep voice, voice cracking in females)
Fat accumulation and weight gain

Metabolism control substances are substances that help the metabolic system work better, causing the body to use energy more efficiently, creating competitive advantages, such as Insulin, Meldonium

Side Effects

Heart works too hard, leading to heart disease
Low blood in extremities including headache,fatigue, dizziness, nausea, irregular heartbeat,blurred vision
Low blood pressure
Insomnia

S5 – DIURETICS AND MASKING AGENTS

Diuretics (DIURETICS) are substances used to reduce water content in the body, or often used to reduce weight quickly in sports that have weight class competitions. Medically, they are used to treat high blood pressure, heart failure, kidney disease, and edema.

Side Effects

Makes the body dehydrate faster than normal, such as electrolyte imbalance
Causes muscles to weaken and may cause sudden muscle cramps
Body loses water, leading to heat exhaustion (Heat exhaust)
Heat stroke – unconsciousness due to body’s inability to regulate heat, can lead to coma or death
Low blood pressure
Abnormal sensory perception
May increase fatigue in some cases, leading to dizziness or sudden fainting

M1 – MANIPULATION OF BLOOD AND BLOOD COMPONENTS

1. Blood doping or reintroduction of blood or blood components into the circulatory system, whether it’s AUTOLOGOUS, ALLOGENIC (HOMOLOGOUS) ORHETEROLOGOUSBLOOD, RED BLOOD CELL PRODUCTS OF ANY ORIGIN INTO THE CIRCULATORY SYSTEM)

2. Artificially enhancing oxygen uptake, transport, or delivery including but not limited to: PERFLUOROCHEMICALS (perfluorocarbon polymers [carbon13]), and haemoglobin products such as haemoglobin-based blood substitutes (HAEMOGLOBIN-BASED BLOOD SUBSTITUTES), microencapsulated haemoglobin products (MICROENCAPSULATED HAEMOGLOBIN PRODUCTS), but not including supplemental oxygen by inhalation (SUPPLEMENTAL OXYGEN BY INHALATION)

3. Any form of intravascular manipulation of blood or blood components by physical or chemical means (MANIPULATION
OF THE BLOOD), BLOOD COMPONENTS

Side Effects

Heart disease and blood clots
Blood viscosity
Blood vessel blockage
lncreased risk of viral infection and cancer

M2 – CHEMICALAND PHYSICAL MANIPULATION

1. TAMPERING Attempting to tamper with the integrity and validity of samples during the doping control process, substitution and/or adulteration

2. INTRAVENOUS INFUSIONS AND/OR INJECTIONS More than 100 milliliters within 12 hours is considered a prohibited method, except for those legitimately received during medical treatments, surgeries, or clinical diagnostic procedures

M3 – GENE AND CELL DOPING

The use of nucleic acids or nucleic acid analogues that may alter genome sequences and/or gene expression by any mechanism. This includes but is not limited to gene editing, gene silencing and gene transfer technologies.

S6 – STIMULANTS

Stimulants are substances that stimulate the heart, affect the functioning of various systems within the body such as increasing blood circulation, causing oxygen to be delivered to muscles more efficiently. Most are commonly found in nasal decongestants, cold medicines, or ADHD medications.

Side Effects

Heart rate irregularity
High blood pressure
Muscle inflammation
Joint inflammation
Circulatory system abnormalities
Nausea, abnormal responses
Seizures

Examples

Pseudoephedrine
Metamfetamine
Sibutramine
Amfetamine
Adrafinil
Modafinil

S7 – NARCOTICS

Addictive substances that once consumed will create both physical and mental dependence that cannot be stopped immediately. Requires increasingly larger amounts leading to physical and mental illness affecting both body and mind. Can cause acute pain.

Side Effects

Fatigue
Sleepy, lazy
Pain
Respiratory system can be suppressed causing difficulty breathing and possibly death from heart failure
Kidney
Hepatitis
Seizures

Examples

Tramadol
Morphine
Cocaine
Opioids

S8 – CANNABINOIDS

Cannabinoids are substances derived from natural or synthetic cannabis. Currently, there are natural cannabis substances like CANNABIS HASHISH and MARIJUANA and synthetic substances like A9-TETRAHYDROCANNABINOL or THC which have many structures. Using cannabis can cause hallucinations and stimulation of muscle movement, reduce pain. If used in large amounts, it can cause addiction even though it can be used in sports. Besides medical use, it also affects both physical and mental health.

Side Effects

Lost consciousness
Drowsiness
Anxiety
Cancer
Loss of memory
Body deterioration
Seizures
Blood vessel disease
Impaired physical performance

S9 – GLUCOCORTICOIDS

This group of substances is widely used in treating various diseases such as reducing tissue inflammation, joint and muscle inflammation, skin diseases, and respiratory diseases. These are synthesized substances that increase blood sugar levels, providing the body with more energy and affecting the immune system’s function.

Examples

Triamcinolone
Prednisone
etamethasome

Side Effects

Infection / Chronic inflammation
Water retention in body
Brittle bones / Osteoporosis
Liver inflammation
Stomach ulcers
Blood vessels are more easily damaged

SUBSTANCES PROHIBITED IN PARTICULAR SPORTS

P1 – BETA BLOCKER

Beta-blockers are prohibited only during competition in the following sports, and will also be prohibited out-of-competition where indicated

Archery
Auto Racing
Billiards and Snooker (all disciplines)
Darts
Golf
Shooting (target)
Underwater Sports (various underwater disciplines)

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